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Evaluation of Several Two-Step Scoring Functions Based on Linear Interaction Energy, Effective Ligand Size, and Empirical Pair Potentials for Prediction of Protein-Ligand Binding Geometry and Free Energy

The performance of several two-step scoring approaches for molecular docking were assessed for their ability to predict binding geometries and free energies. Two new scoring functions designed for “step 2 discrimination” were proposed and compared to our CHARMM implementation of the linear interacti...

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מידע ביבליוגרפי
Main Authors: Rahaman, Obaidur, Estrada, Trilce P., Doren, Douglas J., Taufer, Michela, Brooks, Charles L., Armen, Roger S.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3183351/
https://ncbi.nlm.nih.gov/pubmed/21644546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci1003009
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