Lentviral-mediated RNAi to inhibit target gene expression of the porcine integrin αv subunit, the FMDV receptor, and against FMDV infection in PK-15 cells

BACKGROUND: shRNA targeting the integrin αv subunit, which is the foot-and-mouth disease virus (FMDV) receptor, plays a key role in virus attachment to susceptible cells. We constructed a RNAi lentiviral vector, iαv pLenti6/BLOCK -iT™, which expressed siRNA targeting the FMDV receptor, the porcine i...

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Bibliographic Details
Main Authors: Luo, Jihuai, Du, Junzheng, Gao, Shandian, Zhang, Guofeng, Sun, Jingjing, Cong, Guozheng, Shao, Junjun, Lin, Tong, Chang, Huiyun
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3183033/
https://ncbi.nlm.nih.gov/pubmed/21899738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-8-428
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