High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism

The pathways that comprise cellular metabolism are highly interconnected, and alterations in individual enzymes can have far-reaching effects. As a result, global profiling methods that measure gene expression are of limited value in predicting how the loss of an individual function will affect the...

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Главные авторы: Griffin, Jennifer E., Gawronski, Jeffrey D., DeJesus, Michael A., Ioerger, Thomas R., Akerley, Brian J., Sassetti, Christopher M.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2011
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182942/
https://ncbi.nlm.nih.gov/pubmed/21980284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002251
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