The Human Papillomavirus E6 Oncogene Represses a Cell Adhesion Pathway and Disrupts Focal Adhesion through Degradation of TAp63β upon Transformation

Cervical carcinomas result from cellular transformation by the human papillomavirus (HPV) E6 and E7 oncogenes which are constitutively expressed in cancer cells. The E6 oncogene degrades p53 thereby modulating a large set of p53 target genes as shown previously in the cervical carcinoma cell line He...

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Main Authors: Ben Khalifa, Youcef, Teissier, Sébastien, Tan, Meng-Kwang Marcus, Phan, Quang Tien, Daynac, Mathieu, Wong, Wei Qi, Thierry, Françoise
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182928/
https://ncbi.nlm.nih.gov/pubmed/21980285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002256
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