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GTP-dependent packing of a three-helix bundle is required for atlastin-mediated fusion

The mechanisms governing atlastin-mediated membrane fusion are unknown. Here we demonstrate that a three-helix bundle (3HB) within the middle domain is required for oligomerization. Mutation of core hydrophobic residues within these helices inactivates atlastin function by preventing membrane tether...

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Detalhes bibliográficos
Main Authors: Pendin, Diana, Tosetto, Jessica, Moss, Tyler J., Andreazza, Camilla, Moro, Stefano, McNew, James A., Daga, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182751/
https://ncbi.nlm.nih.gov/pubmed/21930898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106421108
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