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GTP-dependent packing of a three-helix bundle is required for atlastin-mediated fusion
The mechanisms governing atlastin-mediated membrane fusion are unknown. Here we demonstrate that a three-helix bundle (3HB) within the middle domain is required for oligomerization. Mutation of core hydrophobic residues within these helices inactivates atlastin function by preventing membrane tether...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3182751/ https://ncbi.nlm.nih.gov/pubmed/21930898 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106421108 |
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