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Use of mixed Li/K metal TMP amide (LiNK chemistry) for the synthesis of [2.2]metacyclophanes

A new two-step general approach to [2.2]metacyclophane synthesis from substituted m-xylenes is described. The strategy employs a selective benzylic metalation and oxidative C–C bond formation for both synthetic operations. Regioselective benzylic metalation is achieved using the BuLi, KOt-Bu, TMP(H)...

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Detalhes bibliográficos
Main Authors: Blangetti, Marco, Fleming, Patricia, O'Shea, Donal F
Formato: Artigo
Idioma:Inglês
Publicado em: Beilstein-Institut 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182434/
https://ncbi.nlm.nih.gov/pubmed/21977209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.7.145
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