Differential Role of PKA Catalytic Subunits in Mediating Phenotypes Caused by Knockout of the Carney Complex Gene Prkar1a

The Carney complex is an inherited tumor predisposition caused by activation of the cAMP-dependent protein kinase [protein kinase A (PKA)] resulting from mutation of the PKA-regulatory subunit gene PRKAR1A. Myxomas and tumors in cAMP-responsive tissues are cardinal features of this syndrome, which i...

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Bibliographic Details
Main Authors: Yin, Zhirong, Pringle, Daphne R., Jones, Georgette N., Kelly, Kimberly M., Kirschner, Lawrence S.
Format: Artigo
Language:Inglês
Published: Endocrine Society 2011
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182421/
https://ncbi.nlm.nih.gov/pubmed/21852354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2011-1008
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