Hepatocyte Growth Factor stimulated cell scattering requires ERK and Cdc42-dependent Tight Junction Disassembly

The mechanism by which Hepatocyte Growth Factor (HGF) induces tight junction disassembly prior to cell scattering is largely unknown. Here, we show that HGF-stimulates rapid loss of the TJ assembly protein Par6 from the TJ in an Erk-dependent manner. Erk activation by HGF is found to mediate the int...

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Bibliographic Details
Main Authors: Togawa, Akashi, Sfakianos, Jeffery, Ishibe, Shuta, Suzuki, Sayuri, Fujigaki, Yoshihide, Kitagawa, Masatoshi, Mellman, Ira, Cantley, Lloyd G.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182281/
https://ncbi.nlm.nih.gov/pubmed/20728428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2010.08.060
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