Simultaneous Quantification of Intracellular Natural and Antiretroviral Nucleosides and Nucleotides by Liquid Chromatography–Tandem Mass Spectrometry

Nucleoside reverse transcriptase inhibitors (NRTI) require intracellular phosphorylation, which involves multiple enzymatic steps to inhibit the human immunodeficiency virus type 1 (HIV-1). NRTI-triphosphates (NRTI-TP) compete with endogenous 2′-deoxyribonucleosides-5′-triphosphates (dNTP) for incor...

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Hlavní autoři: Fromentin, Emilie, Gavegnano, Christina, Obikhod, Aleksandr, Schinazi, Raymond F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182105/
https://ncbi.nlm.nih.gov/pubmed/20143781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac902737j
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