Simultaneous Quantification of Intracellular Natural and Antiretroviral Nucleosides and Nucleotides by Liquid Chromatography–Tandem Mass Spectrometry

Nucleoside reverse transcriptase inhibitors (NRTI) require intracellular phosphorylation, which involves multiple enzymatic steps to inhibit the human immunodeficiency virus type 1 (HIV-1). NRTI-triphosphates (NRTI-TP) compete with endogenous 2′-deoxyribonucleosides-5′-triphosphates (dNTP) for incor...

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Main Authors: Fromentin, Emilie, Gavegnano, Christina, Obikhod, Aleksandr, Schinazi, Raymond F.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182105/
https://ncbi.nlm.nih.gov/pubmed/20143781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac902737j
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