Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets

It is believed that megakaryocytes undergo a specialized form of apoptosis to shed platelets. Conversely, a range of pathophysiological insults, including chemotherapy, are thought to cause thrombocytopenia by inducing the apoptotic death of megakaryocytes and their progenitors. To resolve this para...

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Detalhes bibliográficos
Main Authors: Josefsson, Emma C., James, Chloé, Henley, Katya J., Debrincat, Marlyse A., Rogers, Kelly L., Dowling, Mark R., White, Michael J., Kruse, Elizabeth A., Lane, Rachael M., Ellis, Sarah, Nurden, Paquita, Mason, Kylie D., O’Reilly, Lorraine A., Roberts, Andrew W., Metcalf, Donald, Huang, David C.S., Kile, Benjamin T.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182050/
https://ncbi.nlm.nih.gov/pubmed/21911424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20110750
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