Sustained activation of the HER1–ERK1/2–RSK signaling pathway controls myoepithelial cell fate in human mammary tissue

Human mammary glands arise from multipotent progenitor cells, which likely respond both to cell-autonomous and to extrinsic cues. However, the identity of these cues and how they might act remain unclear. We analyzed HER1 ligand effects on mammary morphogenesis using a three-dimensional organoid mod...

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Autors principals: Pasic, Lejla, Eisinger-Mathason, T.S. Karin, Velayudhan, Bisi T., Moskaluk, Christopher A., Brenin, David R., Macara, Ian G., Lannigan, Deborah A.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2011
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182019/
https://ncbi.nlm.nih.gov/pubmed/21828273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.2025611
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