Lung Gene Expression in a Rhesus Allergic Asthma Model Correlates with Physiologic Parameters of Disease and Exhibits Common and Distinct Pathways with Human Asthma and a Mouse Asthma Model

Experimental nonhuman primate models of asthma exhibit multiple features that are characteristic of an eosinophilic/T helper 2 (Th2)-high asthma subtype, characterized by the increased expression of Th2 cytokines and responsive genes, in humans. Here, we determine the molecular pathways that are pre...

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Hlavní autoři: Abbas, Alexander R., Jackman, Janet K., Bullens, Sherron L., Davis, Sarah M., Choy, David F., Fedorowicz, Grazyna, Tan, Martha, Truong, Bao-Tran, Gloria Meng, Y., Diehl, Lauri, Miller, Lisa A., Schelegle, Edward S., Hyde, Dallas M., Clark, Hilary F., Modrusan, Zora, Arron, Joseph R., Wu, Lawren C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2011
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3181391/
https://ncbi.nlm.nih.gov/pubmed/21819959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.06.009
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