Identification of a Variable Number of Tandem Repeats Polymorphism and Characterization of LEF-1 Response Elements in the Promoter of the IDO1 Gene

BACKGROUND: Indoleamine 2,3-dioxygenase (IDO) catalyzes the first and rate-limiting step of the kynurenine pathway that is an important component of immunomodulatory and neuromodulatory processes. The IDO1 gene is highly inducible by IFN-γ and TNF-α through interaction with cis-acting regulatory ele...

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Main Authors: Soichot, Marion, Hennart, Benjamin, Al Saabi, Alaa, Leloire, Audrey, Froguel, Philippe, Levy-Marchal, Claire, Poulain-Godefroy, Odile, Allorge, Delphine
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3181322/
https://ncbi.nlm.nih.gov/pubmed/21980470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025470
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