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S-Nitrosylation and S-Palmitoylation Reciprocally Regulate Synaptic Targeting of PSD-95

PSD-95, a principal scaffolding component of the post-synaptic density, is targeted to synapses by palmitoylation where it couples NMDA receptor stimulation to production of nitric oxide (NO) by neuronal nitric oxide synthase (nNOS). Here, we show that PSD-95 is physiologically S-nitrosylated. We id...

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Detalhes bibliográficos
Main Authors: Ho, Gary P. H., Selvakumar, Balakrishnan, Mukai, Jun, Hester, Lynda D., Wang, Yuxuan, Gogos, Joseph A., Snyder, Solomon H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3181141/
https://ncbi.nlm.nih.gov/pubmed/21745643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2011.05.033
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