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MT1-MMP Cleavage of the Anti-angiogenic Proteoglycan Decorin: Role in Corneal Angiogenesis

PURPOSE: Decorin is a small chondroitin sulfate proteoglycan that inhibits vascular endothelial cell migration and tube formation. Membrane type 1-matrix metalloproteinase (MT1-MMP) has been shown to be an important angiogenic enzyme in the cornea. We evaluated the specific role of MT1-MMP in decori...

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Bibliographic Details
Main Authors: Mimura, Tatsuya, Chang, Jin-Hong, Kim, Tae-im, Onguchi, Tatsuya, Kojima, Takashi, Sakimoto, Tohru, Azar, Dimitri T.
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3181092/
https://ncbi.nlm.nih.gov/pubmed/21912230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ICO.0b013e31822816e0
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