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Structure-Activity Relationship for Thiohydantoin Androgen Receptor Antagonists for Castration-Resistant Prostate Cancer (CRPC)

A structure-activity relationship study was carried out on a series of thiohydantoins and their analogues 14 which led to the discovery of 92 (MDV3100) as the clinical candidate for the treatment of hormone refractory prostate cancer.

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Jung, Michael E., Ouk, Samedy, Yoo, Dongwon, Sawyers, Charles L., Chen, Charlie, Tran, Chris, Wongvipat, John
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2010
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3180999/
https://ncbi.nlm.nih.gov/pubmed/20218717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901488g
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