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Identification, localization, and relative quantitation of pseudouridine in RNA by tandem mass spectrometry of hydrolysis products

The constitutional isomers uridine (U) and pseudouridine (Ψ) cannot be distinguished from each other by simple mass measurements of RNA or its fragments because the conversion of U into Ψ is a “mass-silent” post-transcriptional modification. Here we propose a new mass spectrometry based method for i...

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Sonraí Bibleagrafaíochta
Main Authors: Taucher, Monika, Ganisl, Barbara, Breuker, Kathrin
Formáid: Artigo
Teanga:Inglês
Foilsithe: Elsevier 2011
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3180913/
https://ncbi.nlm.nih.gov/pubmed/21960742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijms.2010.05.024
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