On-bead combinatorial synthesis and imaging of CEST-MRI agents to identify factors that influence water exchange

The sensitivity of magnetic resonance imaging (MRI) contrast agents is highly dependent on the rate of water exchange between the inner-sphere of a paramagnetic ion and bulk water. Normally, identifying a paramagnetic complex that has optimal water exchange kinetics is done by synthesizing and testi...

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Bibliographic Details
Main Authors: Napolitano, Roberta, Soesbe, Todd C., De León-Rodríguez, Luis M., Sherry, A. Dean, Udugamasooriya, D. Gomika
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3180893/
https://ncbi.nlm.nih.gov/pubmed/21793515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja201123f
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