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A switch in RND3-RHOA signaling is critical for melanoma cell invasion following mutant-BRAF inhibition

BACKGROUND: The initial use of BRAF targeted therapeutics in clinical trials has demonstrated encouraging responses in melanoma patients, although a rise in drug-resistant cells capable of advancing malignant disease has been described. The current study uses BRAF(V600E )expressing WM793 melanoma ce...

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Bibliografiske detaljer
Main Authors: Klein, R Matthew, Higgins, Paul J
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3180434/
https://ncbi.nlm.nih.gov/pubmed/21917148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-114
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