Tissue inhibitor of metalloproteinases-3 mediates the death of immature oligodendrocytes via TNF-α/TACE in focal cerebral ischemia in mice

BACKGROUND AND PURPOSE: Oligodendrocyte (OL) death is important in focal cerebral ischemia. TIMP-3 promotes apoptosis in ischemic neurons by inhibiting proteolysis of TNF-α superfamily of death receptors. Since OLs undergo apoptosis during ischemia, we hypothesized that TIMP-3 contributes to OL deat...

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Detalhes bibliográficos
Main Authors: Yang, Yi, Jalal, Fakhreya Y, Thompson, Jeffrey F, Walker, Espen J, Candelario-Jalil, Eduardo, Li, Lu, Reichard, Ross R, Ben, Chi, Sang, Qing-Xiang, Cunningham, Lee Anna, Rosenberg, Gary A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3180275/
https://ncbi.nlm.nih.gov/pubmed/21871134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-8-108
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