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Mutation of cysteine 21 inhibits nucleophosmin/B23 oligomerization and chaperone activity
Nucleophosmin (NPM/B23) is a multifunctional nucleolar protein to which both tumor-suppressor and oncogenic functions have been attributed. NPM/B23 has a variety of binding partners including ribosomes, nucleic acids, the centrosome and tumor suppressors such as p53 and p19ARF. These disparate funct...
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Autori principali: | , , , , |
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Natura: | Artigo |
Lingua: | Inglês |
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e-Century Publishing Corporation
2010
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Soggetti: | |
Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3180032/ https://ncbi.nlm.nih.gov/pubmed/21968505 |
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