Mutation of cysteine 21 inhibits nucleophosmin/B23 oligomerization and chaperone activity

Nucleophosmin (NPM/B23) is a multifunctional nucleolar protein to which both tumor-suppressor and oncogenic functions have been attributed. NPM/B23 has a variety of binding partners including ribosomes, nucleic acids, the centrosome and tumor suppressors such as p53 and p19ARF. These disparate funct...

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Bibliographische Detailangaben
Hauptverfasser: Prinos, Panagiotis, Lacoste, Marie-Claude, Wong, Judy, Bonneau, Anne-Marie, Georges, Elias
Format: Artigo
Sprache:Inglês
Veröffentlicht: e-Century Publishing Corporation 2010
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3180032/
https://ncbi.nlm.nih.gov/pubmed/21968505
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