Selectively T cell depleted allografts from HLA-matched sibling donors followed by low-dose post transplant immunosuppression to improve transplant outcome in patients with hematological malignancies

We evaluated a photodepletion technique to selectively deplete host-reacting T cells from HLA-matched sibling stem cell transplants with the goal of reducing post transplant immunosuppression to improve anti-malignancy effects post allografting. Donor lymphocytes were stimulated with irradiated expa...

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Détails bibliographiques
Auteurs principaux: Mielke, S, McIver, Z, Shenoy, A, Fellowes, V, Khuu, H, Stroncek, DF, Leitman, SF, Childs, R, Battiwalla, M, Koklanaris, E, Haggerty, J, Savani, BN, Rezvani, K, Barrett, AJ
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179818/
https://ncbi.nlm.nih.gov/pubmed/21684344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2011.05.019
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