(-)-Epigallocatechin-3-gallate and DZNep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cells

Polycomb group (PcG) protein-dependent histone methylation and ubiquitination drives chromatin compaction leading to reduced tumor suppressor expression and increased cancer cell survival. Green tea polyphenols and S-adenosylhomocysteine (AdoHcy) hydrolase inhibitors are important candidate chemopre...

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Autores principales: Choudhury, Subhasree Roy, Balasubramanian, Sivaprakasam, Chew, Yap Ching, Han, Bingshe, Marquez, Victor E., Eckert, Richard L.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2011
Materias:
Cancer Prevention
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179425/
https://ncbi.nlm.nih.gov/pubmed/21798853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgr171
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