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Modelling basic features of specificity in the binding of a dicationic steroid diamine to double-stranded oligonucleotides.
An investigation of the intrinsically preferred binding modes of a steroid diamine, dipyrandium, to the double-stranded hexanucleotides d(TATATA)2, d(ATATAT)2, and d(CGCGCG)2 is carried out by the energy minimization procedure JUMNA. Several alternative binding modes are compared: groove binding in...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
1989
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC317927/ https://ncbi.nlm.nih.gov/pubmed/2740214 |
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