UNC119 is required for G protein trafficking in sensory neurons

UNC119 is widely expressed among vertebrates and invertebrates. Here we report that UNC119 recognized the acylated N-terminus of the rod photoreceptor transducin α-subunit (Tα) as well as C. elegans G proteins Odr-3 and Gpa-13. The crystal structure of human UNC119 at 1.95 Å resolution revealed an i...

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Hlavní autoři: Zhang, Houbin, Constantine, Ryan, Vorobiev, Sergey, Chen, Yang, Seetharaman, Jayaraman, Huang, Yuanpeng Janet, Xiao, Rong, Montelione, Gaetano T., Gerstner, Cecilia D., Davis, M. Wayne, Inana, George, Whitby, Frank G., Jorgensen, Erik M., Hill, Christopher P., Tong, Liang, Baehr, Wolfgang
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3178889/
https://ncbi.nlm.nih.gov/pubmed/21642972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2835
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