Exploring DNA Topoisomerase I Ligand Space in Search of Novel Anticancer Agents

DNA topoisomerase I (Top1) is over-expressed in tumour cells and is an important target in cancer chemotherapy. It relaxes DNA torsional strain generated during DNA processing by introducing transient single-strand breaks and allowing the broken strand to rotate around the intermediate Top1 – DNA co...

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Detaylı Bibliyografya
Asıl Yazarlar: Drwal, Malgorzata N., Agama, Keli, Wakelin, Laurence P. G., Pommier, Yves, Griffith, Renate
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2011
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3178613/
https://ncbi.nlm.nih.gov/pubmed/21966440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025150
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