β1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism

Maintenance of single layered endothelium, squamous endothelial cell shape, and formation of a patent vascular lumen all require defined endothelial cell polarity. Loss of β1 integrin (Itgb1) in nascent endothelium leads to disruption of arterial endothelial cell polarity and lumen formation. The lo...

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Main Authors: Zovein, Ann C., Luque, Alfonso, Turlo, Kirsten A., Hofmann, Jennifer J., Yee, Kathleen M., Becker, Michael S., Fassler, Reinhard, Mellman, Ira, Lane, Timothy F., Iruela-Arispe, M. Luisa
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3178410/
https://ncbi.nlm.nih.gov/pubmed/20152176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2009.12.006
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