Sub-lytic C5b-9 induces functional changes in retinal pigment epithelial cells consistent with age-related macular degeneration

PURPOSE: There is evidence for complement dysfunction in age-related macular degeneration (AMD). Complement activation leads to formation of the membrane attack complex (MAC), known to assemble on retinal pigment epithelial (RPE) cells. Therefore, the effect of sub-lytic MAC on RPE cells was examine...

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Autori principali: Lueck, K, Wasmuth, S, Williams, J, Hughes, T R, Morgan, B P, Lommatzsch, A, Greenwood, J, Moss, S E, Pauleikhoff, D
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2011
Soggetti:
Laboratory Study
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3178225/
https://ncbi.nlm.nih.gov/pubmed/21597483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/eye.2011.109
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