Krüppel-like factor 4 (KLF4) directly regulates proliferation in thymocyte development and IL-17 expression during Th17 differentiation

Krüppel-like factor 4 (KLF4), a transcription factor, plays a key role in the pluripotency of stem cells. We sought to determine the function of KLF4 in T-cell development and differentiation by using T-cell-specific Klf4-knockout (KO) mice. We found that KLF4 was highly expressed in thymocytes and...

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Detalhes bibliográficos
Main Authors: An, Jie, Golech, Susanne, Klaewsongkram, Jettanong, Zhang, Yongqing, Subedi, Kalpana, Huston, Gail E., Wood, William H., Wersto, Robert P., Becker, Kevin G., Swain, Susan L., Weng, Nanping
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2011
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177573/
https://ncbi.nlm.nih.gov/pubmed/21685331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-186924
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