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Engineering fibrin-binding TGF-β1 for sustained signaling and contractile function of MSC based vascular constructs
We present a strategy to conjugate TGF-β1 into fibrin hydrogels to mimic the in vivo presentation of the growth factor in a 3D context. To this end, we engineered fusion proteins between TGF-β1 and a bi-functional peptide composed of a Factor XIII domain and a plasmin cleavage site. In another versi...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3177033/ https://ncbi.nlm.nih.gov/pubmed/21864893 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2011.07.079 |
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