Mitochondrially localized PKA reverses mitochondrial pathology and dysfunction in a cellular model of Parkinson's disease

Mutations in PTEN-induced kinase 1 (PINK1) are associated with a familial syndrome related to Parkinson's disease (PD). We previously reported that stable neuroblastoma SH-SY5Y cell lines with reduced expression of endogenous PINK1 exhibit mitochondrial fragmentation, increased mitochondria-der...

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Autori principali: Dagda, R K, Gusdon, A M, Pien, I, Strack, S, Green, S, Li, C, Van Houten, B, Cherra, S J, Chu, C T
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2011
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Original Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177020/
https://ncbi.nlm.nih.gov/pubmed/21637291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.74
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