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Potential prostate cancer drug target: Bioactivation of androstanediol by conversion to dihydrotestosterone

High affinity binding of dihydrotestosterone (DHT) to the androgen receptor (AR) initiates androgen-dependent gene activation required for normal male sex development in utero, and contributes to prostate cancer development and progression in men. Under normal physiological conditions, DHT is synthe...

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Main Authors: Mohler, James L., Titus, Mark A., Wilson, Elizabeth M.
格式: Artigo
語言:Inglês
出版: 2011
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177006/
https://ncbi.nlm.nih.gov/pubmed/21705451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-0644
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