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Potential prostate cancer drug target: Bioactivation of androstanediol by conversion to dihydrotestosterone
High affinity binding of dihydrotestosterone (DHT) to the androgen receptor (AR) initiates androgen-dependent gene activation required for normal male sex development in utero, and contributes to prostate cancer development and progression in men. Under normal physiological conditions, DHT is synthe...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2011
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3177006/ https://ncbi.nlm.nih.gov/pubmed/21705451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-0644 |
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