The Functioning of the Drosophila CPEB Protein Orb Is Regulated by Phosphorylation and Requires Casein Kinase 2 Activity

The Orb CPEB protein regulates translation of localized mRNAs in Drosophila ovaries. While there are multiple hypo- and hyperphosphorylated Orb isoforms in wild type ovaries, most are missing in orb(F303), which has an amino acid substitution in a buried region of the second RRM domain. Using a prot...

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Main Authors: Wong, Li Chin, Costa, Alexandre, McLeod, Ian, Sarkeshik, Ali, Yates, John, Kyin, Saw, Perlman, David, Schedl, Paul
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3176278/
https://ncbi.nlm.nih.gov/pubmed/21949709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024355
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