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Rigorous assessment and integration of the sequence and structure based features to predict hot spots
BACKGROUND: Systematic mutagenesis studies have shown that only a few interface residues termed hot spots contribute significantly to the binding free energy of protein-protein interactions. Therefore, hot spots prediction becomes increasingly important for well understanding the essence of proteins...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3176265/ https://ncbi.nlm.nih.gov/pubmed/21798070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-12-311 |
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