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Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D(2) autoreceptors

Dopamine (DA) D(2) receptors expressed in DA neurons (D(2) autoreceptors) exert a negative feedback regulation that reduces DA neuron firing, DA synthesis and DA release. As D(2) receptors are mostly expressed in postsynaptic neurons, pharmacological and genetic approaches have been unable to defini...

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Autors principals: Bello, Estefanía P, Mateo, Yolanda, Gelman, Diego M, Noaín, Daniela, Shin, Jung H, Low, Malcolm J, Alvarez, Verónica A, Lovinger, David M, Rubinstein, Marcelo
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175737/
https://ncbi.nlm.nih.gov/pubmed/21743470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2862
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