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Structural basis for the role of the Sir3 AAA(+) domain in silencing: interaction with Sir4 and unmethylated histone H3K79
The silent information regulator 2/3/4 (Sir2/3/4) complex is required for gene silencing at the silent mating-type loci and at telomeres in Saccharomyces cerevisiae. Sir3 is closely related to the origin recognition complex 1 subunit and consists of an N-terminal bromo-adjacent homology (BAH) domain...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3175719/ https://ncbi.nlm.nih.gov/pubmed/21896656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.17175111 |
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