c-Myc dependent expression of pro-apoptotic Bim renders HER2-overexpressing breast cancer cells dependent on anti-apoptotic Mcl-1

BACKGROUND: Anti-apoptotic signals induced downstream of HER2 are known to contribute to the resistance to current treatments of breast cancer cells that overexpress this member of the EGFR family. Whether or not some of these signals are also involved in tumor maintenance by counteracting constitut...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Campone, Mario, Noël, Bélinda, Couriaud, Cécile, Grau, Morgan, Guillemin, Yannis, Gautier, Fabien, Gouraud, Wilfried, Charbonnel, Catherine, Campion, Loïc, Jézéquel, Pascal, Braun, Frédérique, Barré, Benjamin, Coqueret, Olivier, Barillé-Nion, Sophie, Juin, Philippe
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2011
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175201/
https://ncbi.nlm.nih.gov/pubmed/21899728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-110
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