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A new mechanism for antiepileptic drug action: vesicular entry may mediate the effects of levetiracetam

Levetiracetam (LEV) is one of the most commonly prescribed antiepileptic drugs, but its mechanism of action is uncertain. Based on prior information that LEV binds to the vesicular protein synaptic vesicle protein 2A and reduces presynaptic neurotransmitter release, we wanted to more rigorously char...

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Detalhes bibliográficos
Principais autores: Meehan, Anna L., Yang, Xiaofeng, McAdams, Brian D., Yuan, LiLian, Rothman, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174821/
https://ncbi.nlm.nih.gov/pubmed/21653714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00279.2011
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