Convergent evolution of two mammalian neuronal enhancers by sequential exaptation of unrelated retroposons

The proopiomelanocortin gene (POMC) is expressed in a group of neurons present in the arcuate nucleus of the hypothalamus. Neuron-specific POMC expression in mammals is conveyed by two distal enhancers, named nPE1 and nPE2. Previous transgenic mouse studies showed that nPE1 and nPE2 independently dr...

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Detalles Bibliográficos
Main Authors: Franchini, Lucía F., López-Leal, Rodrigo, Nasif, Sofía, Beati, Paula, Gelman, Diego M., Low, Malcolm J., de Souza, Flávio J. S., Rubinstein, Marcelo
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174587/
https://ncbi.nlm.nih.gov/pubmed/21876128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104997108
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