The Role of Factor XIa (FXIa) Catalytic Domain Exosite Residues in Substrate Catalysis and Inhibition by the Kunitz Protease Inhibitor Domain of Protease Nexin 2

To select residues in coagulation factor XIa (FXIa) potentially important for substrate and inhibitor interactions, we examined the crystal structure of the complex between the catalytic domain of FXIa and the Kunitz protease inhibitor (KPI) domain of a physiologically relevant FXIa inhibitor, prote...

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Detalhes bibliográficos
Main Authors: Su, Ya-Chi, Miller, Tara N., Navaneetham, Duraiswamy, Schoonmaker, Robert T., Sinha, Dipali, Walsh, Peter N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173081/
https://ncbi.nlm.nih.gov/pubmed/21778227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.257527
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