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Enhanced spontaneous activity of the mu opioid receptor by cysteine mutations: characterization of a tool for inverse agonist screening.

BACKGROUND: The concept of spontaneous- or constitutive-activity has become widely accepted and verified for numerous G protein-coupled receptors and this ligand-independent activity is also acknowledged to play a role in some pathologies. Constitutive activity has been reported for the mu opioid re...

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Hlavní autoři: Brillet, Karl, Kieffer, Brigitte L, Massotte, Dominique
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2003
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC317294/
https://ncbi.nlm.nih.gov/pubmed/14641935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2210-3-14
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