Sorafenib and dacarbazine as first-line therapy for advanced melanoma: phase I and open-label phase II studies

METHOD: The safety of oral sorafenib up to a maximum protocol-specified dose combined with dacarbazine in patients with metastatic, histologically confirmed melanoma was investigated in a phase I dose-escalation study and the activity of the combination was explored in an open-label phase II study....

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Main Authors: Eisen, T, Marais, R, Affolter, A, Lorigan, P, Robert, C, Corrie, P, Ottensmeier, C, Chevreau, C, Chao, D, Nathan, P D, Jouary, T, Harries, M, Negrier, S, Montegriffo, E, Ahmad, T, Gibbens, I, James, M G, Strauss, U P, Prendergast, S, Gore, M E
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2011
主題:
Clinical Study
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172912/
https://ncbi.nlm.nih.gov/pubmed/21750549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.257
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