Crystal structure and function of human nucleoplasmin (Npm2): a histone chaperone in oocytes and embryos

Human Npm2 is an ortholog of Xenopus nucleoplasmin (Np), a chaperone that binds histones. We have determined the crystal structure of a truncated Npm2-core at 1.9Å resolution and show that the N-terminal domains of Npm2 and Np form similar pentamers. This allowed us to model an Npm2 decamer which ma...

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Bibliografiske detaljer
Main Authors: Platonova, Olga, Akey, Ildikó V., Head, James F., Akey, Christopher W.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172369/
https://ncbi.nlm.nih.gov/pubmed/21863821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2006652
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