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Activation of Rac1 by a Crk SH3-binding protein, DOCK180

DOCK180 is involved in integrin signaling through CrkII-p130(Cas) complexes. We have studied the involvement of DOCK180 in Rac1 signaling cascades. DOCK180 activated JNK in a manner dependent on Rac1, Cdc42Hs, and SEK, and overexpression of DOCK180 increased the amount of GTP-bound Rac1 in 293T cell...

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Detaylı Bibliyografya
Asıl Yazarlar: Kiyokawa, Etsuko, Hashimoto, Yuko, Kobayashi, Shin, Sugimura, Haruhiko, Kurata, Takeshi, Matsuda, Michiyuki
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cold Spring Harbor Laboratory Press 1998
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC317231/
https://ncbi.nlm.nih.gov/pubmed/9808620
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