NF-κB Induction of the SUMO Protease SENP2: A Negative Feedback Loop to Attenuate Cell Survival Response to Genotoxic Stress

Activation of NF-κB, pivotal for immunity and oncogenesis, is tightly controlled by multiple feedback mechanisms. In response to DNA damage, SUMOylation of NEMO (NF-κB essential modulator) is critical for NF-κB activation, however SUMO proteases and feedback mechanisms involved remain unknown. Here...

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Main Authors: Lee, Moon Hee, Mabb, Angela M., Gill, Grace B., Yeh, Edward T., Miyamoto, Shigeki
格式: Artigo
語言:Inglês
出版: 2011
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172129/
https://ncbi.nlm.nih.gov/pubmed/21777808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.06.017
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