Combined Bicarbonate Conductance-Impairing Variants in CFTR and SPINK1 Are Associated with Chronic Pancreatitis in Patients without Cystic Fibrosis

BACKGROUND & AIMS: Idiopathic chronic pancreatitis (ICP) is a complex inflammatory disorder associated with multiple genetic and environmental factors. In individuals without cystic fibrosis (CF), variants of CFTR that inhibit bicarbonate conductance but maintain chloride conductance might selec...

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Main Authors: Schneider, Alexander, LaRusch, Jessica, Sun, Xiumei, Aloe, Amy, Lamb, Janette, Hawes, Robert, Cotton, Peter, Brand, Randall E., Anderson, Michelle A., Money, Mary E., Banks, Peter A., Lewis, Michele D., Baillie, John, Sherman, Stuart, DiSario, James, Burton, Frank R., Gardner, Timothy B., Amann, Stephen T., Gelrud, Andres, George, Ryan, Kassabian, Sirvart, Martinson, Jeremy, Slivka, Adam, Yadav, Dhiraj, Oruc, Nevin, Barmada, M. Michael, Frizzell, Raymond, Whitcomb, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3171690/
https://ncbi.nlm.nih.gov/pubmed/20977904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.10.045
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