Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway

RAD53 and MEC1 are essential genes required for the transcriptional and cell cycle responses to DNA damage and DNA replication blocks. We have examined the essential function of these genes and found that their lethality but not their checkpoint defects can be suppressed by increased expression of g...

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Detalhes bibliográficos

Publicado no:	Genes Dev
Principais autores:	Desany, Brian A., Alcasabas, Annette A., Bachant, Jeffrey B., Elledge, Stephen J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Cold Spring Harbor Laboratory Press 1998
Assuntos:	Research Paper
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317167/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9744871/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.12.18.2956
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