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Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface

We have determined the crystal structure, at 3.2 Å, of a ternary complex containing an OCA-B peptide, the Oct-1 POU domain, and an octamer DNA site. The OCA-B peptide binds in the major groove near the center of the octamer site, and its polypeptide backbone forms a pair of hydrogen bonds with the a...

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Udgivet i:Genes Dev
Principais autores: Chasman, Daniel, Cepek, Karyn, Sharp, Phillip A., Pabo, Carl O.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 1999
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317104/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10541551/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.20.2650
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