Glycosylation of Twisted Gastrulation is Required for BMP Binding and Activity during Craniofacial Development

Twisted gastrulation (TWSG1) is a conserved, secreted glycoprotein that modulates signaling of bone morphogenetic proteins (BMPs) in the extracellular space. Deletion of exon 4 of mouse Twsg1 (mTwsg1) is associated with significant craniofacial defects. However, little is understood about the bioche...

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Detalhes bibliográficos
Main Authors: Billington, Charles J., Fiebig, Juliane E., Forsman, Cynthia L., Pham, Lan, Burbach, Nathan, Sun, Mu, Jaskoll, Tina, Mansky, Kim, Gopalakrishnan, Rajaram, O’Connor, Michael B., Mueller, Thomas D., Petryk, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Research Foundation 2011
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3170884/
https://ncbi.nlm.nih.gov/pubmed/21941513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2011.00059
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