DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair

The human single-stranded DNA-binding replication A protein (RPA) is involved in various DNA-processing events. By comparing the affinity of hRPA for artificial DNA hairpin structures with 3′- or 5′-protruding single-stranded arms, we found that hRPA binds ssDNA with a defined polarity; a strong ssD...

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Main Authors: de Laat, Wouter L., Appeldoorn, Esther, Sugasawa, Kaoru, Weterings, Eric, Jaspers, Nicolaas G.J., Hoeijmakers, Jan H.J.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 1998
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Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC317078/
https://ncbi.nlm.nih.gov/pubmed/9716411
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